Our Commitment to Evidence-Based Formulations

Scientific Research at KYGENESIS®

At KYGENESIS®, we believe the best approach to long-term kidney and metabolic health is one rooted in evidence. Each of our ingredients has been carefully selected based on clinical studies, institutional publications, or long-standing traditional use backed by modern science. While our formulas are not intended to diagnose, treat, or cure disease, they are designed to support your body with real, researched benefits.

Clinical and In Vivo Research

These ingredients have been studied and shown to support kidney function, filtration, blood sugar, inflammation, and cardiovascular health.

In Vitro and Mechanism-Based Studies

These ingredients are supported by laboratory or mechanistic research showing antioxidant, anti-inflammatory, or metabolic effects relevant to kidney and systemic wellness.

Meet the experts behind the best kidney healing method.

Our team of experienced naturopaths and health professionals brings decades of clinical knowledge, compassionate care, and a shared mission: to empower people with kidney disease to heal naturally and avoid dialysis. With backgrounds in naturopathy, nutrition, functional medicine, education, and herbal therapy, these are the trusted experts behind our science-backed solutions and KYGENESIS® supplements—supporting you at every step of your kidney health journey.

  • Comprehensive Research Summary:

    Kidney-Related Clinical Studies

  • Alehagen, U.; Aaseth, J.; Larsson, A.; Alexander, J. - Cells 2022, 11, 509.

    Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q10

    This sub-analysis investigated the effects of selenium and CoQ10 on FGF-23 levels, a biomarker associated with cardiovascular health and CKD outcomes in elderly individuals.

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  • Bi X, Yang K, Zhang B, Zhao J. - Kidney Dis (Basel). 2020 Nov;6(6):395-406.

    The Protective Role of Klotho in CKD-Associated Cardiovascular Disease

    Klotho protein protects against vascular calcification and heart remodeling, supporting its therapeutic relevance in CKD-related cardiovascular disease.

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  • Buchanan S, Combet E, Stenvinkel P, Shiels PG - Front. Endocrinol. 11:560. 2020.

    Klotho, Aging, and the Failing Kidney

    This review describes how reduced Klotho expression accelerates renal aging, contributing to the progression of CKD.

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  • Chen J, Siriki R - Am J Nephrol 2015;42:318-319.

    Antioxidants Therapy for Patients with Chronic Kidney Disease: A Question of Balance

    The commentary highlights the need for balanced antioxidant therapy in CKD patients, due to potential interactions and dosage concerns.

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  • Chen K, Wang S, Sun QW, et al. - Circ Res. 2021;128(4):492-507.

    Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

    Klotho deficiency impairs antioxidant signaling pathways, leading to cardiac aging, a common comorbidity in CKD.

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  • Daenen K, et al. - Pediatr Nephrol. 2019;34(6):975-991.

    Oxidative Stress in Chronic Kidney Disease

    Oxidative stress plays a central role in CKD pathophysiology, affecting progression and complications like anemia and cardiovascular disease.

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  • Dennis JM, Witting PK - Nutrients. 2017;9(7):718.

    Protective Role for Antioxidants in Acute Kidney Disease

    Summarizes evidence for antioxidants as protective agents in acute kidney injury, with possible relevance to chronic conditions.

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  • Eugenio‐Pérez D, et al. - IntechOpen. 2016.

    Role of Dietary Antioxidant Agents in Chronic Kidney Disease

    Outlines how natural antioxidants in food can reduce oxidative damage in CKD, supporting integrative dietary interventions.

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  • Han C, Jiang YH, et al. - J Ethnopharmacol. 2020;269:113768.

    Astragalus membranaceus and Salvia miltiorrhiza Ameliorate Cyclosporin A-Induced Chronic Nephrotoxicity

    These herbs protect renal tissue through gut-kidney axis modulation, offering promise for reducing nephrotoxic drug side effects.

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  • Huang K-C, Su Y-C, Sun M-F, Huang S-T - Front. Pharmacol. 2018;9:1117.

    Chinese Herbal Medicine Improves Long-Term Survival in CKD Patients

    Population-based study shows that traditional herbal medicine can enhance survival outcomes when integrated with CKD care.

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  • Jun M, Venkataraman V, et al. - Cochrane Database Syst Rev. 2012;10:CD008176.

    Antioxidants for Chronic Kidney Disease

    This Cochrane review evaluates antioxidant supplements in CKD patients, showing limited but promising evidence in slowing progression.

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  • Jurado-Fasoli L, Castillo MJ, Amaro-Gahete FJ - Nutrients. 2020;12(2):281.

    Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

    Higher dietary inflammation scores correlate with lower Klotho levels, emphasizing the importance of an anti-inflammatory diet in aging and CKD.

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  • Lai Q, Wei J, et al. - Drug Des Devel Ther. 2015;9:4997-5018.

    Pharmacokinetic and Nephroprotective Benefits of Schisandra chinensis Extracts

    Schisandra chinensis mitigates cyclosporine-induced nephrotoxicity, offering support for its use in immune-compromised CKD patients.

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  • L Gupta K, Sahni N - J Nephropathol. 2012;1(3):134-42.

    Dietary Antioxidants and Oxidative Stress in Predialysis CKD Patients

    This observational study links low intake of dietary antioxidants to elevated oxidative stress markers in CKD stages 1–4.

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  • Lim SW, et al. - Aging (Albany NY). 2019;11(15):5548–5569.

    Ginseng Increases Klotho Expression via FoxO3 Pathway

    In a tacrolimus-induced renal injury model, ginseng activated Klotho expression, enhancing kidney resilience to damage.

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  • Ling XC, Kuo KL - Ren Replace Ther. 2018;4:53.

    Oxidative Stress in Chronic Kidney Disease

    Oxidative stress drives inflammation, fibrosis, and progression in CKD. The review advocates antioxidants as complementary therapy.

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  • Liu W, Gao Y, et al. - Front. Pharmacol. 2022.

    Mechanism of Cordyceps sinensis in Diabetic Kidney Disease

    Cordyceps sinensis is shown to modulate key diabetic and inflammatory pathways, making it a candidate for diabetic nephropathy treatment.

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  • Lobo V, Patil A, Phatak A, Chandra N - Pharmacogn Rev. 2010;4(8):118–26.

    Free Radicals, Antioxidants and Functional Foods: Impact on Human Health

    This review outlines antioxidant roles in reducing oxidative stress, a common contributor to CKD and other chronic illnesses.

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  • Luo K, Yu JH, et al. - Sci Rep. 2019;9:7995.

    Therapeutic Potential of Coenzyme Q10 in Mitochondrial Dysfunction

    CoQ10 improves mitochondrial function and cellular health in tacrolimus-injured pancreatic beta cells, with renal implications.

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  • Minamizaki T, Konishi Y, et al. - J Endocrinol. 2018;237(3):285–300.

    Soluble Klotho Causes Hypomineralization in Klotho-Deficient Mice

    Study reveals paradoxical effects of soluble Klotho on bone mineralization, relevant for CKD patients at risk of bone disorders.

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  • Ostojic SM, Engeset D - Front. Nutr. 2021;8:795599.

    Improving Brain Creatine Uptake by Klotho Protein Stimulation

    The review discusses Klotho’s potential to improve brain creatine uptake, with implications for anti-aging and neuroprotection in CKD.

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  • Piao SG, Kang SH, et al. - Transplantation. 2013;96(2):146-153.

    Influence of N-acetylcysteine on Klotho in Chronic Cyclosporine Nephropathy

    NAC upregulates Klotho expression and reduces oxidative stress in nephrotoxicity models, supporting its adjunctive use in CKD.

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  • Podkowińska A, Formanowicz D - Antioxidants. 2020;9:752.

    Chronic Kidney Disease as Oxidative Stress- and Inflammatory-Mediated Cardiovascular Disease

    This article describes CKD as both a cardiovascular and oxidative/inflammatory condition, promoting a broader treatment paradigm.

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  • Prud’homme GJ, Kurt M, Wang Q - Front. Aging. 2022;3:931331.

    Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations

    A detailed look at Klotho’s multifaceted role in aging and chronic disease, supporting it as a drug target in kidney and vascular health.

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  • Rapa SF, Di Iorio BR, et al. - Int J Mol Sci. 2019;21(1):263.

    Inflammation and Oxidative Stress in CKD: Therapeutic Role of Minerals, Vitamins, and Plants

    Presents evidence on how specific vitamins, minerals, and plant-derived compounds can mitigate CKD-related oxidative stress.

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  • Shen CY, Jiang JG, et al. - Br J Pharmacol. 2017;174:1395–1425.

    Anti-aging Ingredients from Herbs and Nutraceuticals

    Analyzes anti-aging mechanisms of herbal compounds and how they might contribute to kidney and systemic longevity.

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  • Shibu MA, Lin YJ, et al. - Biomed Pharmacother. 2022;146:112427.

    Jing Si Herbal Formula Displays Anti-Aging Effects

    Jing Si, a traditional herbal blend, shows protective benefits in aging-related disorders, potentially relevant to renal aging.

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  • Typiak M, Piwkowska A - Int J Mol Sci. 2021;22(2):956.

    Antiinflammatory Actions of Klotho in Diabetic Nephropathy

    Explores Klotho’s role in reducing renal inflammation and fibrosis in diabetic patients, advocating for its therapeutic activation.

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  • Yang XH, Zhang BL, et al. - Oxid Med Cell Longev. 2020; Article ID 6092715.

    EGCG Reverses Klotho Hypermethylation in Diabetic Mice

    EGCG, from green tea, restores Klotho gene activity and improves renal outcomes in diabetic nephropathy models.

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  • Yu JH, Lim SW, et al. - FASEB J. 2019;33(11):12288-12298.

    Coenzyme Q10 Alleviates Tacrolimus-Induced Mitochondrial Dysfunction

    CoQ10 improves mitochondrial health in tacrolimus-injured kidney tissue, supporting its role in nephroprotective protocols.

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  • Zhang N, Ma X, et al. - Front Pharmacol. 2022;13:914157.

    Cordyceps sinensis Improves Diabetic Kidney Disease via Inhibition of TGF-β1/Smad Pathway

    Cordyceps sinensis reduces renal fibrosis and inflammation in diabetic kidney disease models by modulating the TGF-β1/Smad signaling pathway.

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