New Formula

Kygenesis Alkalizing Formula Stages 4-5

For Kidney Stages 4‒5

  • Supports normal pH
  • Protects the kidney from acidity
  • Helps to counter the effects of inflammation
  • Supports purification of the kidneys
  • Protects against oxidative stress
  • Aids in maintaining a healthy urinary tract

$49.00 or Original price was: $49.00.Current price is: $39.20. / month

(Price in USD)

Subscription Discount Chart - Up to 30% Off!

Month Price
1 - 2 $49.00
3 - 4 $36.75
5+ $34.30
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orders ship within 24 hrs

Savings on all Bulk Orders

Up to 30% Savings
on all Subscriptions

Made In the USA

Made In the USA

GMP Certified

GMP Certified Facility

Science-Based Formula

Science-Based Formulas

Increase Your Alkalinity with Kygenesis® Alkalizing Formula™


Every cell, tissue, and organ in your body functions at a specific pH. If your pH acidifies even slightly, your body must quickly restore the alkaline balance with help from the kidneys.

When kidney function is impaired, so is your ability to excrete acids to maintain balance. Yet, keeping the body alkaline protects your kidneys from further damage.
That’s why we developed Kygenesis® Alkalizing FormulaTM. Available in two unique blends for Kidneys Stages 1 to 3 and Kidneys Stages 4 to 5, it’s the only alkaline supplement that’s tailored to your specific needs.

Discover Kygenesis® Alkalizing Formula™ Active Ingredients

Kidney Stages 4‒5

Kygenesis® Alkalizing FormulaTM Kidney Stages 4‒5 delivers alkaline relief with sodium bicarbonate, proven to protect kidneys from damage related to acidosis. 

We’ve added a select blend of nutrients and herbs that promote the health of your kidneys, heart, blood sugar, and more while defending against oxidative stress and boosting immunity.

Read on to discover why our team of Naturopaths chose these exact ingredients for Stages 4‒5.

(Do you have an eGFR higher than 35? Kygenesis® Alkaline  FormulaTM Kidney Stages 1‒3 is formulated just for you.) 

Sodium Bicarbonate

Sodium bicarbonate is the closest substitute we have for the electrolyte, bicarbonate, that our bodies naturally produce. Bicarbonate helps to regulate a healthy pH.
Read More

Zinc Citrate

Zinc enhances the immune system, aids in metabolism, speeds wound healing, tissue repair, and detoxification.
Read More

Sour Cherry Extract

Sour cherry is a botanical supplement that’s highly beneficial for the kidneys, blood sugar, heart, joints, and sleep. That’s because tart cherries are exceptionally high in key antioxidants and nutrients.

Read More


Taurine is an amino acid with potent antioxidant and anti-inflammatory properties. Studies show that taurine is often depleted in those with low kidney function.

Read More

Parsley Leaf

Parsley is a nutrient-dense herb that supports kidney function and urinary tract health in multiple ways. It’s also high in antioxidants and vitamins that support whole-body health.
Read More

Nettle Leaf

Nettle leaf has a long history of use in traditional medicine, in part for its use as a diuretic.
Read More

Kygenesis® Alkalizing Formula: Created for Your Kidney Stage & Nutrition Needs

Kygenesis® Alkalizing FormulaTM Kidneys Stages 4‒5 helps normalize pH for those with an eGFR under 35.

At Stages 4‒5, your kidneys are not working as they should, you may have symptoms and health complications. 

You want an alkalizing supplement that’s based on a proven treatment for managing acidosis (sodium bicarbonate).

At the same time, you want to reduce the side effects of bicarbonate therapy with herbs and nutrients that support healthy blood pressure and reduce water retention.

We designed Kygenesis® Alkalizing FormulaTM Kidneys Stages 4‒5 to protect your kidneys from further damage while improving your energy, sleep, stress, and everyday comfort.

(Do you have an eGFR over 35? Try Kygenesis® Alkalizing FormulaTM for Kidneys Stages 1‒3.)

How to Use Kygenesis® Alkalizing Formula

for Kidneys Stages 4‒5

Protecting your kidneys from acidity is easy with Kygenesis® Alkalizing FormulaTM.

Dosage & Preparation:

Dissolve one scoop (8.8 gm) of powder in cold water and stir thoroughly before drinking.

Taken alone, you’ll notice the Alkalizing Formula has a tart-bitter taste, which stimulates the liver.

There are no added sweeteners in this supplement by design. Most sweeteners are acidifying. An alkaline exception is stevia, an herbal sweetener. You can add stevia or blend the alkaline powder with a fruit smoothie. Please avoid dairy, which is also acidifying.

When to Take Alkalizing Formula:


Take Kygenesis® Alkalizing FormulaTM once a day, ideally first thing in the morning before eating breakfast. We recommend waiting 30 minutes before taking food, to allow the supplements to pass through to your bloodstream. 

For decades, we’ve been recommending these very supplements to clients in clinical practice

Kygenesis® is founded by Naturopaths who specialize in kidney wellness.


We know the power of nutritional supplements and herbs because we’ve seen the results first-hand, in our clinics and in our coaching practice.


Until we created Kygenesis, no other line of kidney-specific nutritional and herbal supports existed. At least, not in pure and concentrated formulas.


So, we formulated every Kygenesis® supplement ourselves.

Based on evidence from decades of clinical experience, medical research, and thousands of years of traditional herbal therapeutics, we know these ingredients are remarkably effective.


Now you can support your kidneys and total health with supplements formulated by Naturopaths just for you.

Kygenesis® Alkalizing Formula is Part of the Kidney Support Protocol

NEW Kygenesis® Alkalizing Formulais a complement to the supplements in our complete Kidney Support Protocol:

Kidney Advance™ is a concentrated nutritional formula that bridges gaps in even the healthiest diet, delivering clinically proven micro-nutrients to the kidneys and every cell in your body. 


Kidney Prime™ is a blend of high-potency herbal extracts, 4x to 10x more potent than similar supplements. It’s rich in phytonutrients, adaptogens, and bio-modulators that are clinically proven to promote healthy kidney tissues, reduce creatinine and urea.


Kidney Tea includes the herbs that are best taken in liquid form. When steeped in hot water, these herbs are rapidly absorbed, so you get faster relief from water retention, urinary discomfort, and stress.


For the best results, combine the above Kidney Support Protocol with the healthy lifestyle practices outlined in the Kidney Coach™ program under the supervision of your doctor.

Get the Kygenesis® Alkalizing Formula

Next Day Shipping

Next Day Shipping
orders ship within 24 hrs

Savings on all Bulk Orders

Up to 30% Savings
on all Subscriptions

Alkalizing FormulaTM FAQs

Kygensis Alkalizing Formula Kidney Stages 4‒5 is formulated specifically for those with diagnosed loss of kidney function and an eGFR under 35.

If you have mild loss of kidney functionality (eGFR over 35) please use Kygensis Alkalizing Formula Kidney Stages 1‒3. The formula for those with an eGFR over 35 is also suitable for anyone interested in prevention of CKD. Supporting a healthy pH and reducing the acid load on your kidneys is essential for anyone, and the nutrients, antioxidants, and phytochemicals in this formula can help to keep your kidneys healthy.

In Stages 4‒5 of CKD, or when your eGFR is under 35, high doses of magnesium should be avoided. When kidney functionality is low, there is a risk that your magnesium levels may become too high.

Sodium bicarbonate taken orally is an effective alternative to magnesium as an alkalizing agent. Studies show that bicarbonate therapy slows the decline in kidney function in more advanced CKD and in the presence of metabolic acidosis.

Bicarbonate is widely accepted as the therapy of choice for restoring pH balance in later stages of kidney functionality. 


As a supplement, sodium bicarbonate can cause some gastrointestinal discomfort, such as gas or bloating. 

Your doctor should also monitor you for edema and hypertension because of the sodium. The Alkalizing Formula includes ingredients that act as diuretics and anti-hypertensives to offset the effects of sodium bicarbonate.

At this stage, sodium bicarbonate is the best therapy available for acidosis, and the protective effects of sodium bicarbonate do outweigh the risks.

This is the only alkalizing supplement of its kind custom-formulated for kidneys. In addition to the alkalizing bicarbonate, we’ve added five powerfully protective ingredients. 

Formulating kidney supplements is our sole focus. This formula and every supplement from Kygenesis®is formulated by Naturopaths who have deep clinical experience with kidney wellness. We select every ingredient based on gold standard nutritional research and then find the highest-quality sources in the world. 

Magnesium is rapidly absorbed into the bloodstream and can deliver relief from stress, anxiety, difficulty sleeping, and constipation within the same day.

However, the real benefits of an alkaline supplement are long-term as you protect your kidneys from damage and ward off symptoms of declining functionality.

Before taking Kygenesis, be sure you have the results from blood work. Repeat the blood tests after 3-4 months of consistently taking Kygenesis® daily.

You can gauge your progress towards achieving a healthy acid-alkaline balance by using at-home pH strips. These strips are available for purchase at pharmacies, testing is simple and you can learn more in the Kidney Disease Solution e-book.

We also recommend keeping a daily symptom diary. When you take the complete Kygenesis® Kidney Protocol, a sense of well-being, improved energy, and mental clarity are often the first noticeable improvements.

Kygenesis® supplements are most effective when combined with a diet that promotes kidney health, exercise, and meditation, or other practices that reduce stress.

Vitamin C is one of the major nutrients we recommend to patients who have started to lose kidney function. As a supplement, it is protective in so many ways. (See this article for more information.)

There is a misconception that you can’t take vitamin C if you are at risk of kidney stones. This myth arose out of an assumption that has largely been discredited by research.

Vitamin C is one of the most studied nutrients and is backed by the highest volume of clinical trials. We have an overwhelming body of evidence that vitamin C is highly safe for general use and for those with kidney damage.

Large-scale human trials conducted over 14+ years demonstrated that vitamin C does not increase kidney stones. In our extensive research, we have yet to see a study that shows vitamin C causes kidney stones. In fact, some studies suggest that vitamin C may actually decrease kidney stones.

We would only err on the side of caution in using vitamin C if you have very high oxalates and compromised liver function. Even then, we would recommend vitamin C immediately after getting your liver function back up.

Kygenesis® is made from ingredients that are deemed safe for the general population when taken as recommended. If you have a pre-existing health condition, are pregnant or lactating, consult a healthcare professional before using any nutritional supplement.
Some pharmaceuticals cannot be taken with specific nutritional supplements. In other cases, a supplement may have an “additive effect”, increasing the effects of medication. If you are taking any medication we recommend speaking to your professional health care provider or emailing customer support at [email protected].

Kygenesis® is formulated to support kidney function but we cannot recommend that you substitute these supplements for prescribed medication or recommended over-the-counter medication.

Please consult with your qualified healthcare practitioner for advice on your medication.

Magnesium is an essential mineral that is eliminated from the body daily and must be replaced daily. Most people don’t get enough magnesium through diet (especially true if you are on a kidney diet) and that’s why symptoms of deficiency are so common. If your eGFR is above 35, a daily magnesium supplement will help to bridge any gaps in your diet.

Your body’s pH also requires constant balancing, and impaired kidneys need help eliminating the acid from your body with help from an alkaline “buffer”. By taking Kygenesis® Alkalizing FormulaTM daily, you can support a healthy pH balance and reduce the load on your kidneys.

Zinc and vitamin C are also water-soluble and excreted from the body daily. Both are essential nutrients that our bodies cannot produce, and most people with kidney damage are at risk of deficiency in both. These nutrients are critical to kidney health, which is why we recommend both as part of a long-term supplement regimen. 

The complete formula is dense with antioxidants, anti-inflammatory compounds, and phytochemicals that your body needs daily to defend your kidneys and total health.

This supplement is calibrated for maximum efficacy and safety at the recommended dose — not above. Please follow the dosage guidelines or as directed by your healthcare professional.

Domestic US and international shipping costs vary depending on the shipping method you choose at checkout. You will see the shipping costs in your checkout process and can adjust your shipping method before placing your order.

Kygenesis® is prepared in New York, at a multi-award-winning FDA registered facility, certified GMP by NSF International through independent audits. The chemists and technicians operate to the highest standards of quality.

Please email our Customer Service at [email protected]

Get the Kygenesis Alkalizing Formula

Next Day Shipping

Next Day Shipping
orders ship within 24 hrs

Savings on all Bulk Orders

Up to 30% Savings
on all Subscriptions

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.